David Ortiz hits career homer No. 400

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David Ortiz became the 49th player in big-league history to reach 400 homers when he took Oakland’s A.J. Griffin deep in the fourth inning Wednesday.

It was Ortiz’s 22nd homer of 2012, putting him into a tie for fifth place in the American League. The 36-year-old will be the AL’s starting DH in next week’s All-Star Game.

Ortiz’s Hall of Fame chances appeared next to nil a couple of years ago, but his big resurgence has put him back into the discussion. He has a chance at 500 career homers, and he turned in an outstanding five-year peak from 2003-07 in which he finished in the top-five in the AL MVP balloting every year. He also helped lead the Red Sox to World Series championships in that span.

Of course, there is the steroid taint, even if the only thing that ties him to it is that a couple of lawyers reportedly said his name was on the “anonymous list” of players testing positive in 2003.

Regardless, Ortiz is on pace for a historic season. He’s on pace to become the fifth different player in major league history to hit at least .300 with 40 homers and 100 RBI at 36 or older. Babe Ruth did it twice, Hank Aaron once, Andres Galarraga twice and Barry Bonds three times.

Red Sox end Astros’ 10-game winning streak

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The Red Sox salvaged the final game of their three-game home series against the Astros, winning 4-3 on Sunday afternoon. In doing so, they ended the Astros’ 10-game winning streak.

Xander Bogaerts struck the decisive blow, knocking in a run with a double in the seventh inning to break a 3-3 tie. Michael Chavis also hit another homer — his eighth of the season — while Mookie Betts collected three hits and scored three runs to raise his OPS to .899.

The Astros last lost on May 7 against the Royals, the second game of a three-game series. The Astros won the final game of that set, then swept the Rangers in a four-game series, the Tigers in three, and won the first two games against the Red Sox. It’s their second 10-game winning streak of the season, as they won 10 striaght between April 5-16, sweeping the Athletics, Yankees, and Mariners before losing the second of two games against the A’s in Oakland.

At 31-16, the Astros are slightly behind the Twins — in progress as of this writing — for the best winning percentage in the majors. The Red Sox, meanwhile, have made up some ground after ending April 13-17. They’re now 24-22, good for third place in the AL East.