Johan Santana is struggling since his no-hitter

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Did the 134 pitches take a toll? After getting lit up by the Yankees last week, Johan Santana gave up four runs in five-plus innings Thursday versus the Rays in his second start since his no-hitter.

The 134 pitches Santana threw in shutting down the Cardinals were a career high for the left-hander, who was handled carefully during the first two months in his first season back from shoulder surgery. Pitching on six days’ rest last Friday, he gave up six runs and four homers in five innings in a loss to the Yankees. Today, working on five days’ rest, he got a win, but he allowed four runs in five-plus innings.

It actually should have been worse. Santana loaded the bases with no outs in the sixth, giving up a single to Hideki Matsui, a double to Ben Zobrist and a walk to Matt Joyce. Jon Rauch took over and managed to strand all three runners by getting two strikeouts and then a groundout.

Santana threw just 51 of his 95 pitches for strikes in this one. He issued four walks, his second highest total of the season (he walked five in the no-hitter).

Santana’s ERA has jumped from 2.38 to 3.23 since the no-no and would be higher if not for Rauch’s effort. The Mets have to be hoping its an aberration, not a trend. Santana and R.A. Dickey have been an outstanding one-two punch so far, but Santana needs to return to May form to keep that up.

Brandon Crawford homers off brother-in-law Gerrit Cole

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You can’t pick your family and no one knows that better than Giants shortstop Brandon Crawford. His sister Amy married Astros starter Gerrit Cole in November 2016, so the two players are brothers-in-law.

The two players have matched up against each other 18 times in the past, as Cole spent his first five seasons in the National League with the Pirates. Cole often won that battle, holding Crawford to four hits — all singles — in 18 plate appearances.

Crawford finally got the better of Cole on Tuesday night, hitting a line drive into the appropriately-named Crawford Boxes at Minute Maid Park for a two-run home run, cutting the Astros’ lead to 5-2.