Odrisamer Despaigne loses his no-hitter with two outs in the eighth inning

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Update (6:35 PM ET): Despaigne lost his no-hitter after recording back-to-back strikeouts of Kirk Nieuwenhuis and Curtis Granderson. Daniel Murphy ripped a high fastball for a double to left-center. David Wright followed up with a ground ball single up the middle to score Murphy. Despaigne departs having allowed the one run and two hits over 7 2/3 innings. He walked three, hit two batters, and struck out five on 123 pitches.

Padres starter Odrisamer Despaigne has no-hit the Mets through seven innings this afternoon. He hasn’t been perfect by any means, as he has walked three and hit two batters with baseballs. He loaded the bases with two outs on two walks and a hit batter before escaping the seventh. Despaigne will enter the eighth inning having thrown 100 pitches.

Catcher Yasmani Grandal gave his pitcher some run support, blasting a solo home run to right-center off of Zack Wheeler in the fourth inning. The Padres have scratched out eight hits but have managed only the one run.

Despaigne, making his fifth career start, has been great for the Padres. He entered the afternoon with a 1.35 ERA and a 12/8 K/BB ratio over 26 2/3 innings.

We’ll keep you updated as Despaigne progresses through the game in an attempt to throw the first no-hitter in Padres history. The Mets were last victims of a no-hitter on September 8, 1993, when Astros starter Darryl Kile accomplished the feat. The Padres, of course, watched a no-hitter earlier this season when Giants starter Tim Lincecum held them hitless on June 25.

Rockies activate Ian Desmond from the disabled list

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The Rockies activated first baseman Ian Desmond from the 10-day disabled list on Sunday, the club announced. Cristhian Adames was designated for assignment to create roster space. Desmond is in Sunday’s lineup against the Diamondbacks, batting sixth.

Desmond, 31, signed a five-year, $70 million contract with the Rockies in December. In March, he was unfortunately hit by a pitch and suffered a broken left hand. He underwent surgery to repair the damage.

Desmond had been playing in extended spring training as a precursor to rehab games, but he looked so good that the Rockies decided to activate him from the disabled list a little early.

Aaron Sanchez exits game after one inning with a split fingernail

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This wasn’t how Aaron Sanchez was supposed to make his triumphant return from the disabled list. The Blue Jays’ right-hander was activated for his first start on Sunday after undergoing a minor surgical procedure to have part of his fingernail removed. According to MLB.com’s Gregor Chisholm, the surgery should have accelerated the healing process for a troublesome blister, and the team appeared confident in the right-hander’s ability to take the mound for the tail end of their homestand. Instead, Sanchez lasted just 13 pitches before exiting the game with a split nail on his right middle finger.

The team has yet to address Sanchez’s revised timetable for return, but Chisholm points out that they should be able to roll with their current rotation through May 9. If he sits out longer, the Jays could turn to left-hander J.A. Happ, who should be eligible to start sometime next month after he makes a full recovery from a bout of left elbow inflammation.

Sanchez, 24, entered Sunday with a 4.38 ERA, 2.9 BB/9 and 6.6 SO/9 through 12 1/3 innings with Toronto. He was replaced by right-handed reliever Ryan Tepera in the top of the second inning.