David Ortiz hits career homer No. 400

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David Ortiz became the 49th player in big-league history to reach 400 homers when he took Oakland’s A.J. Griffin deep in the fourth inning Wednesday.

It was Ortiz’s 22nd homer of 2012, putting him into a tie for fifth place in the American League. The 36-year-old will be the AL’s starting DH in next week’s All-Star Game.

Ortiz’s Hall of Fame chances appeared next to nil a couple of years ago, but his big resurgence has put him back into the discussion. He has a chance at 500 career homers, and he turned in an outstanding five-year peak from 2003-07 in which he finished in the top-five in the AL MVP balloting every year. He also helped lead the Red Sox to World Series championships in that span.

Of course, there is the steroid taint, even if the only thing that ties him to it is that a couple of lawyers reportedly said his name was on the “anonymous list” of players testing positive in 2003.

Regardless, Ortiz is on pace for a historic season. He’s on pace to become the fifth different player in major league history to hit at least .300 with 40 homers and 100 RBI at 36 or older. Babe Ruth did it twice, Hank Aaron once, Andres Galarraga twice and Barry Bonds three times.

Dodgers designate Sergio Romo for assignment

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The Dodgers announced on Thursday that the club activated pitcher Grant Dayton from the 10-day disabled list and designated pitcher Sergio Romo for assignment.

Dayton, 29, went on the disabled list earlier this month with neck stiffness. He’ll resume with a 3.63 ERA and a 20/12 K/BB ratio in 22 1/3 innings.

Romo, 34, signed a one-year, $3 million deal with the Dodgers in February. It didn’t really work out, as the right-hander posted a 6.12 ERA with a 31/12 K/BB ratio in 25 innings. His peripherals are still decent, so it wouldn’t be surprising if a team in need of a bullpen arm makes a deal with the Dodgers within the week.

Nate Karns underwent season-ending surgery for thoracic outlet syndrome

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MLB.com’s Jeffrey Flanagan reports that Royals pitcher Nate Karns underwent surgery for thoracic outlet syndrome on Wednesday. He’s expected to be ready for spring training next year. Karns went on the disabled list in May with an elbow injury and didn’t make much progress.

The Royals acquired Karns from the Mariners in January in exchange for outfielder Jarrod Dyson. Over eight starts and one relief appearance, the 29-year-old right-hander compiled a 4.17 ERA and a 51/13 K/BB ratio in 45 1/3 innings.

Karns will enter his first of three years of arbitration eligibility after the season, so he’ll be under the Royals’ control through 2020.