Flawless: Matt Cain throws a perfect game versus Astros

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Matt Cain turned in one of the most dominant performances in recent memory Wednesday night, going 27 up and 27 down against the Astros for the 22nd perfect game in MLB history.

Cain was overpowering with 14 strikeouts, which ties Sandy Koufax for the most ever in a perfect game. And the Giants right-hander also got a little help from his defense as left fielder Melky Cabrera made a leaping catch at the wall in the sixth inning and right fielder Gregor Blanco preserved the perfection with a fantastic diving catch at the warning track in the seventh inning.

Cain made quick work of the Astros in the ninth inning, entering the final frame with 114 pitches and then needing just 11 more to get a foul out, a fly out, and a game-ending ground out to third base. Oh, and the Giants won 10-0.

Philip Humber threw the last perfect game on April 21 of this season, striking out nine and setting the Mariners down in order on just 94 pitches. This is just the second time in modern baseball history that there have been two perfect games in the same season, with the other being 2010 when Dallas Braden and Roy Halladay both accomplished the feat.

Sean Manaea has a no-hitter through eight innings

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UPDATE (11:06 PM ET): Manaea is through eight innings of his no-hitter. He caught Rafael Devers looking, then induced a pop-up to retire Sandy Leon and whiffed Jackie Bradley Jr. to end the inning. He’s at 95 pitches and a career-high 10 strikeouts entering the ninth.

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Athletics southpaw Sean Manaea has no-hit the Red Sox through seven innings of Saturday’s game. Any thought of a perfect game was banished in the first at-bat, when Mookie Betts drew a leadoff six-pitch walk to open the first inning. From there, Manaea held the Sox to just three total baserunners through the first seven innings.

Andrew Benintendi tried to break up the no-no in the sixth inning, collecting an infield hit for what appeared to be the Red Sox’ first hit of the evening. Upon further review, however, the hit was reversed after Benintendi incurred a batter interference call for running outside the baseline.

Manaea is currently working with a three-run lead thanks to RBI doubles from Jed Lowrie and Stephen Piscotty and Marcus Semien‘s solo shot off of Chris Sale in the fifth. He’s racked up eight strikeouts against 23 batters so far.

If Manaea sees the no-hitter through to completion — as seems entirely possible, given that his pitch count is resting at 84 entering the eighth — he’ll be the first A’s pitcher to toss a no-no since Dallas Braden’s perfect game against the Rays eight years ago. The last time the Red Sox were on the losing end of a no-hitter, meanwhile, was back in 1993 against the Mariners’ Chris Bosio.