Flawless: Matt Cain throws a perfect game versus Astros

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Matt Cain turned in one of the most dominant performances in recent memory Wednesday night, going 27 up and 27 down against the Astros for the 22nd perfect game in MLB history.

Cain was overpowering with 14 strikeouts, which ties Sandy Koufax for the most ever in a perfect game. And the Giants right-hander also got a little help from his defense as left fielder Melky Cabrera made a leaping catch at the wall in the sixth inning and right fielder Gregor Blanco preserved the perfection with a fantastic diving catch at the warning track in the seventh inning.

Cain made quick work of the Astros in the ninth inning, entering the final frame with 114 pitches and then needing just 11 more to get a foul out, a fly out, and a game-ending ground out to third base. Oh, and the Giants won 10-0.

Philip Humber threw the last perfect game on April 21 of this season, striking out nine and setting the Mariners down in order on just 94 pitches. This is just the second time in modern baseball history that there have been two perfect games in the same season, with the other being 2010 when Dallas Braden and Roy Halladay both accomplished the feat.

Video: Gift Ngoepe singles in his first major league at-bat

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Pirates infielder Gift Ngoepe, just called up from Triple-A Indianapolis, singled in his first major league at-bat on Wednesday evening against Cubs starter Jon Lester. It was a well-struck ground ball up the middle in the bottom of the fourth inning. Unfortunately for him, the Pirates could not bring him around to score.

Ngoepe, who was pinch-hitting, stayed in the game to play second base.

Shelby Miller getting third opinion on elbow from Dr. James Andrews

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Diamondbacks starter Shelby Miller was placed on the 10-day disabled list on Monday due to inflammation in his right elbow. He had a second opinion from Dr. Neal ElAttrache on Tuesday and is currently awaiting a third opinion from Dr. James Andrews, Craig Grialou of Arizona Sports reports. That he’s getting a third opinion seems to imply that Miller’s elbow issue is rather serious.

Miller, 26, hasn’t been able to catch a break since joining the Diamondbacks. Last year’s nightmarish season included a finger injury stemming from mechanical woes and a brief demotion to the minor leagues. In 20 starts in the majors last year, Miller posted an ugly 6.15 ERA. This year, his ERA is a mediocre 4.09 over four starts.

The Diamondbacks called up Zack Godley to take Miller’s spot in the rotation. There was some speculation that it would be Archie Bradley instead, but he’s been working out of the bullpen.