Matt Cain sets a new standard for perfection

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With his 125-pitch gem against the Astros on Wednesday night, Matt Cain entered the history books, throwing the 20th perfect game since 1900 and 22nd in major league history.

Cain struck out 14 in the contest, matching Sandy Koufax’s total on Sept. 9, 1965 for the highest strikeout total in a perfect game.

That gave him a game score of 101, which is tied for the second highest in major league history for a pitcher in a nine-inning game. Of course, Koufax, who had the same line, matched him there, as did Nolan Ryan in his 16-strikeout no-hitter in 1991. The top game score in a nine-inning game is 105, from Kerry Wood’s 20-strikeout, one-hitter against the Astros in 1998.

Making Cain’s feat more impressive:

– The Giants exploded for 10 runs in the game, resulting in some lengthy waits for Cain in the third and fourth innings.

– The wind was blowing out at AT&T Park for the second night in a row. The Giants had gone 16 straight home games without a homer before hitting two on Tuesday night. Tonight, they hit three homers. The Astros wouldn’t have necessarily needed to get all of one to ruin the perfect game and the shutout bid in one swing. Chris Snyder almost spoiled things in the sixth, only to come up a bit short.

– He got to face opposing pitcher J.A. Happ just once, and position players accounted for 26 of the Astros’ 27 plate appearances tonight. While the Astros aren’t exactly known for having a high-powered offense, they entered the night ranked eighth in runs scored in the NL.

Cain’s perfect game was the first in the Giants’ long history. The 14 strikeouts was a new career high for him.

“I can’t thank [catcher] Buster [Posey] enough,” Cain told MLB.com’s Chris Haft. “I didn’t even question him once. What he was calling, I was going to throw whatever he wanted and I was going to let him go. Buster did an unbelievable job back there. That was tremendous.”

Phillies, Red Sox interested in Carlos Santana

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The Phillies and Red Sox appear intent on pursuing free agent first baseman Carlos Santana, MLB Network’s Jon Morosi reports. Santana rejected a one-year, $17.4 million qualifying offer from the Indians on Thursday and is expected to draw widespread interest on the market this winter. The Mets, Mariners, Angels and Indians could make a play for the infielder, though no serious offers have been made this early in the offseason.

Santana, 31, is coming off of a seven-year track with the Indians. He batted .259/.363/.455 with 23 home runs and 3.0 fWAR last season, making 2017 the fourth-most valuable year of his career to date. Although he was primarily stationed at first base over the last year, he could step back into a hybrid first base/DH role with the Red Sox, who are hurting for infield depth with Hanley Ramirez still working his way back from shoulder surgery.

As for Santana’s other suitors, the Mariners are far less likely to pursue a deal after trading for Ryon Healy last Wednesday. Neither the Mets nor the Phillies have a DH spot to offer the veteran infielder, and the Phillies’ Rhys Hoskins appears to be blocking the way at first base. Then again, Santana may not find a more enticing offer outside of Cleveland, where Edwin Encarnacion might otherwise be the club’s best option at first base. During the GM meetings, Indians’ GM Mike Chernoff said he “love to have both [Santana and Jay Bruce] back” in 2018, but hasn’t backed up that love with any contract talks just yet.